Current Research on the Bioprospection of Linear Diterpenes from Bifurcaria bifurcata: From Extraction Methodologies to Possible Applications
authors Pais, ACS; Saraiva, JA; Rocha, SM; Silvestre, AJD; Santos, SAO
nationality International
journal MARINE DRUGS
author keywords Bifurcaria bifurcata; linear diterpenes; extraction; identification; biological activities; macroalgae; high value applications
keywords GERANYLGERANIOL-DERIVED DITERPENES; BIOACTIVE COMPOUNDS; CRUDE EXTRACTS; ANTIMICROBIAL ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIFOULING ACTIVITY; PHENOLIC CONTENT; ALGA; ELEGANOLONE; CYSTOSEIRACEAE
abstract Marine resources are considered as a very promising source of bioactive molecules, and macroalgae in particular have gained special attention, due to their structurally diverse composition. Particular interest has been devoted to the brown macroalga Bifurcaria bifurcata, due to their abundance in bioactive linear diterpenes. In this appraisal, a thorough review concerning the methodologies used in the extraction, fractionation, and identification of diterpenes from B. bifurcata is provided and discussed in detail. An exhaustive compilation of the mass spectra and nuclear magnetic resonance (NMR) data are also provided. The in vitro and in chemico assays already performed to assess different biological activities attributed to B. bifurcata diterpenes are also reviewed, emphasizing the use of isolated components, enriched fractions, or crude extracts. The associated major strengths and challenges for the exploitation of B. bifurcata diterpenes for high-value applications are critically discussed.
publisher MDPI
year published 2019
volume 17
issue 10
digital object identifier (doi) 10.3390/md17100556
web of science category Chemistry, Medicinal
subject category Pharmacology & Pharmacy
unique article identifier WOS:000498064500016
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journal impact factor 4.379
5 year journal impact factor 4.186
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