Nanogrooved microdiscs for bottom-up modulation of osteogenic differentiation
| authors | Bjorge, IM; Choi, IS; Correia, CR; Mano, JF |
| nationality | International |
| journal | NANOSCALE |
| keywords | MESENCHYMAL STEM-CELLS; SUBSTRATE TOPOGRAPHY; NANOSCALE; MICROPARTICLES; MORPHOLOGY; BEHAVIOR |
| abstract | Grooved topographical features have effectively modulated cell differentiation on two-dimensional substrates. To transpose patterning into a 3D environmment, nanogrooved microdiscs, topodiscs, are produced as cell carriers for bottom-up cell-mediated assembly. While enhancing cell proliferation, topodiscs led to the formation of bone-like aggregates, even in culture medium lacking osteoinductive factors. |
| publisher | ROYAL SOC CHEMISTRY |
| issn | 2040-3364 |
| isbn | 2040-3372 |
| year published | 2019 |
| volume | 11 |
| issue | 35 |
| beginning page | 16214 |
| ending page | 16221 |
| digital object identifier (doi) | 10.1039/c9nr06267j |
| web of science category | Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied |
| subject category | Chemistry; Science & Technology - Other Topics; Materials Science; Physics |
| unique article identifier | WOS:000485971900004 |
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impact metrics
| journal analysis (jcr 2019): |
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| journal impact factor | 6.895 |
| 5 year journal impact factor | 7.315 |
| category normalized journal impact factor percentile | 82.576 |
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