authors |
Bjorge, IM; Choi, IS; Correia, CR; Mano, JF |
nationality |
International |
journal |
NANOSCALE |
keywords |
MESENCHYMAL STEM-CELLS; SUBSTRATE TOPOGRAPHY; NANOSCALE; MICROPARTICLES; MORPHOLOGY; BEHAVIOR |
abstract |
Grooved topographical features have effectively modulated cell differentiation on two-dimensional substrates. To transpose patterning into a 3D environmment, nanogrooved microdiscs, topodiscs, are produced as cell carriers for bottom-up cell-mediated assembly. While enhancing cell proliferation, topodiscs led to the formation of bone-like aggregates, even in culture medium lacking osteoinductive factors. |
publisher |
ROYAL SOC CHEMISTRY |
issn |
2040-3364 |
isbn |
2040-3372 |
year published |
2019 |
volume |
11 |
issue |
35 |
beginning page |
16214 |
ending page |
16221 |
digital object identifier (doi) |
10.1039/c9nr06267j |
web of science category |
Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied |
subject category |
Chemistry; Science & Technology - Other Topics; Materials Science; Physics |
unique article identifier |
WOS:000485971900004
|