Cuttlefish Bone-Derived Biphasic Calcium Phosphate Scaffolds Coated with Sol-Gel Derived Bioactive Glass
authors Neto, AS; Brazete, D; Ferreira, JMF
nationality International
journal MATERIALS
author keywords cuttlefish bone; biphasic calcium phosphate; porous scaffolds; sol-gel coatings; bioactivity; tissue engineering
keywords OF-THE-ART; IN-VITRO; ZN; HYDROXYAPATITE; CERAMICS; ZINC; SR; MG
abstract The combination of calcium phosphates with bioactive glasses (BG) has received an increased interest in the field of bone tissue engineering. In the present work, biphasic calcium phosphates (BCP) obtained by hydrothermal transformation of cuttlefish bone (CB) were coated with a Sr-, Mg- and Zn-doped sol-gel derived BG. The scaffolds were characterized by X-ray diffraction, Fourier transform infrared spectroscopy and scanning electron microscopy. The initial CB structure was maintained after hydrothermal transformation (HT) and the scaffold functionalization did not jeopardize the internal structure. The results of the in-vitro bioactivity after immersing the BG coated scaffolds in simulated body fluid (SBF) for 15 days showed the formation of apatite on the surface of the scaffolds. Overall, the functionalized CB derived BCP scaffolds revealed promising properties, but further assessment of the in-vitro biological properties is needed before being considered for their use in bone tissue engineering applications.
publisher MDPI
isbn 1996-1944
year published 2019
volume 12
issue 17
digital object identifier (doi) 10.3390/ma12172711
web of science category Materials Science, Multidisciplinary
subject category Materials Science
unique article identifier WOS:000488880300064
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  impact metrics
journal analysis (jcr 2019):
journal impact factor 3.057
5 year journal impact factor 3.424
category normalized journal impact factor percentile 58.121
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