Lipidomics Reveals Similar Changes in Serum Phospholipid Signatures of Overweight and Obese Pediatric Subjects
authors Anjos, S; Feiteira, E; Cerveira, F; Melo, T; Reboredo, A; Colombo, S; Dantas, R; Costa, E; Moreira, A; Santos, S; Campos, A; Ferreira, R; Domingues, P; Domingue, MRM
nationality International
journal JOURNAL OF PROTEOME RESEARCH
author keywords pediatrics; obesity; diagnostic methods; phospholipids; lipid metabolism; lipidomics
keywords POLYUNSATURATED FATTY-ACIDS; PLASMA PHOSPHOLIPIDS; INDUCED INFLAMMATION; INSULIN-RESISTANCE; METABOLIC SYNDROME; CHILDHOOD OBESITY; PROFILE; LIPIDS; DISEASE; ADIPOSE
abstract Obesity is a public health problem and a risk factor for pathologies such type 2 diabetes mellitus, cardiovascular diseases, and nonalcoholic fatty liver disease. Given these clinical implications, there is a growing interest to understand the pathophysiological mechanism of obesity. Changes in lipid metabolism have been associated with obesity and obesity-related complications. However, changes in the lipid profile of obese children have been overlooked. In the present work, we analyzed the serum phospholipidome of overweight and obese children by HILIC-MS/MS and GC-MS. Using this approach, we have identified 165 lipid species belonging to the classes PC, PE, PS, PG, PI, LPC, and SM. The phospholipidome of overweight (OW) and obese (OB) children was significantly different from normal-weight children (control). Main differences were observed in the PI class that was less abundant in OW and OB children and some PS, PE, SM, and PC lipid species are upregulated in obese and overweight children. Although further studies are needed to clarify some association between phospholipid alterations and metabolic changes, our results highlight the alteration that occurs in the serum phospholipid profile in obesity in children.
publisher AMER CHEMICAL SOC
issn 1535-3893
isbn 1535-3907
year published 2019
volume 18
issue 8
beginning page 3174
ending page 3183
digital object identifier (doi) 10.1021/acs.jproteome.9b00249
web of science category Biochemical Research Methods
subject category Biochemistry & Molecular Biology
unique article identifier WOS:000480370800017
  ciceco authors
  impact metrics
journal analysis (jcr 2019):
journal impact factor 4.074
5 year journal impact factor 3.946
category normalized journal impact factor percentile 85.065
dimensions (citation analysis):
altmetrics (social interaction):



 


Sponsors

1suponsers_list_ciceco.jpg