Synthesis of 4,5-disubstituted-1H-1,2,3-triazoles
authors Rocha, DHA; Pinto, DCGA; Silva, AMS
nationality International
journal MONATSHEFTE FUR CHEMIE
author keywords Alkyne; Cycloaddition; NMR spectroscopy; Heterocycles
keywords AZIDE-ALKYNE CYCLOADDITION; ONE-POT SYNTHESIS; CLICK CHEMISTRY; BIOLOGICAL EVALUATION; ACID-CHLORIDES; 1,4-DISUBSTITUTED 1,2,3-TRIAZOLES; SONOGASHIRA REACTION; PALLADIUM CATALYST; TERMINAL ALKYNES; LIQUID-CRYSTALS
abstract Two-step procedure, a palladium catalyzed Sonogashira cross-coupling reaction of aroyl chlorides with aryl acetylenes, and 1,3-dipolar cycloaddition of the 1,3-diarylprop-2-yn-1-ones with sodium azide under catalyst free conditions achieved the synthesis of aryl(4-aryl-1H-1,2,3-triazol-5-yl)methanones in moderate-to-good chemical yields (30-90%). The procedures allowed the synthesis of 4,5-disubstituted-1H-1,2,3-triazol scaffolds containing electron-neutral, -withdrawing, or -donating groups. [GRAPHICS] .
publisher SPRINGER WIEN
issn 0026-9247
isbn 1434-4475
year published 2019
volume 150
issue 8
beginning page 1479
ending page 1486
digital object identifier (doi) 10.1007/s00706-019-02463-x
web of science category Chemistry, Multidisciplinary
subject category Chemistry
unique article identifier WOS:000477624300010
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journal analysis (jcr 2019):
journal impact factor 1.349
5 year journal impact factor 1.194
category normalized journal impact factor percentile 27.401
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