Magnetic Driven Nanocarriers for pH-Responsive Doxorubicin Release in Cancer Therapy
authors Nogueira, J; Soares, SF; Amorim, CO; Amaral, JS; Silva, C; Martel, F; Trindade, T; Daniel-da-Silva, AL
nationality International
journal MOLECULES
author keywords doxorubicin; magnetic nanoparticles; iron oxide; kappa-carrageenan; drug carrier; pH-responsive
keywords IRON-OXIDE NANOPARTICLES; CONTROLLED DRUG-RELEASE; DELIVERY-SYSTEMS; IN-VITRO; LIPOSOMAL DOXORUBICIN; HYDROGEL BEADS; CHITOSAN; SPECTROSCOPY; CARRAGEENAN; TUMOR
abstract Doxorubicin is one of the most widely used anti-cancer drugs, but side effects and selectivity problems create a demand for alternative drug delivery systems. Herein we describe a hybrid magnetic nanomaterial as a pH-dependent doxorubicin release carrier. This nanocarrier comprises magnetic iron oxide cores with a diameter of 10 nm, enveloped in a hybrid material made of siliceous shells and ?-carrageenan. The hybrid shells possess high drug loading capacity and a favorable drug release profile, while the iron oxide cores allows easy manipulation via an external magnetic field. The pH responsiveness was assessed in phosphate buffers at pH levels equivalent to those of blood (pH 7.4) and tumor microenvironment (pH 4.2 and 5). The nanoparticles have a loading capacity of up to 12.3 wt.% and a release profile of 80% in 5 h at acidic pH versus 25% at blood pH. In vitro drug delivery tests on human breast cancer and non-cancer cellular cultures have shown that, compared to the free drug, the loaded nanocarriers have comparable antiproliferative effect but a less intense cytotoxic effect, especially in the non-cancer cell line. The results show a clear potential for these new hybrid nanomaterials as alternative drug carriers for doxorubicin.
publisher MDPI
isbn 1420-3049
year published 2020
volume 25
issue 2
digital object identifier (doi) 10.3390/molecules25020333
web of science category Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
subject category Biochemistry & Molecular Biology; Chemistry
unique article identifier WOS:000515381800095
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journal analysis (jcr 2019):
journal impact factor 3.267
5 year journal impact factor 3.589
category normalized journal impact factor percentile 56.714
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