Bacterial nanocellulose membranes loaded with vitamin B-based ionic liquids for dermal care applications
authors Chantereau, G; Sharma, M; Abednejad, A; Vilela, C; Costa, EM; Veiga, M; Antunes, F; Pintado, MM; Sebe, G; Coma, V; Freire, MG; Freire, CSR; Silvestre, AJD
nationality International
journal JOURNAL OF MOLECULAR LIQUIDS
author keywords Bacterial nanocellulose; Vitamin B; Ionic liquids; Cholinium-based ILs; Skin care applications; Antioxidant activity
keywords CELLULOSE MEMBRANES; BIOCELLULOSE MEMBRANES; TRANSDERMAL DELIVERY; RELEASE; HYDROCHLORIDE; ACIDS
abstract The development of innovative bio-based skin care products has received an increased attention in the latter years. In the present work, the synthesis of original active principle ingredients based on ionic liquids (ILs) with cholinium cation and vitamins B anions, followed by their incorporation in bacterial nanocellulose (BC) membranes for topical applications, is reported. ThreelLs, namely cholinium nicotinate [Ch][B3], cholinium pantothenate [Ch][B5] and cholinium pyridoxylate [Ch][B6], were synthesized through a metathesis reaction and their structure characterized in detail. Thermal analysis confirmed their denomination as ILs and their high thermal resistance. The solubility of these ILs was higher than their vitamin precursors, especially in the case of [Ch][B3] whose solubility increased 30.6-fold enhancing the bioavailability of this vitamin. The incorporation of Its in BC led to translucent and homogeneous membranes stable up to 190 degrees C. ILs acted as plasticizers reducing BC brittleness that facilitated their application on irregular skin regions. Moreover, the re-hydration ability of BC-ILs membranes was improved 2.9 to 4.8-fold in comparison to BC, ensuring adequate hydration for ILs release, while the release of ILs in buffer solutions was more complete and faster than the release of vitamins. Finally, BC-as were proven not cytotoxic to skin epithelial cells and thus are suitable materials for skin care applications. (C) 2020 Elsevier B.V. All rights reserved.
publisher ELSEVIER
issn 0167-7322
year published 2020
volume 302
digital object identifier (doi) 10.1016/j.molliq.2020.112547
web of science category Chemistry, Physical; Physics, Atomic, Molecular & Chemical
subject category Chemistry; Physics
unique article identifier WOS:000518870300063
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journal analysis (jcr 2019):
journal impact factor 5.065
5 year journal impact factor 4.766
category normalized journal impact factor percentile 81.277
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