authors |
Ramos, PAB; Moreirinha, C; Silva, S; Costa, EM; Veiga, M; Coscueta, E; Santos, SAO; Almeida, A; Pintado, MM; Freire, CSR; Silva, AMS; Silvestre, AJD |
nationality |
International |
journal |
ANTIOXIDANTS |
author keywords |
Salix spp. bark polar extracts; phenolic compounds; antioxidant activity; anti-hypertensive potential; antibacterial effect; bioeconomy-based value chain |
keywords |
HIGH-PERFORMANCE LIQUID; ANTIOXIDANT ACTIVITY; CHEMICAL-COMPOSITION; ANTIMICROBIAL ACTIVITY; ENDOTHELIAL-CELLS; MASS-SPECTROMETRY; WILLOW; HPLC; PROANTHOCYANIDINS; PHYTOCHEMICALS |
abstract |
Salix spp. have been exploited for energy generation, along with folk medicine use of bark extracts for antipyretic and analgesic benefits. Bark phenolic components, rather than salicin, have demonstrated interesting bioactivities, which may ensure the sustainable bioprospection of Salix bark. Therefore, this study highlights the detailed phenolic characterization, as well as the in vitro antioxidant, anti-hypertensive, Staphylococcus aureus growth inhibitory effects, and biocompatibility of Salix atrocinerea Brot., Salix fragilis L., and Salix viminalis L. bark polar extracts. Fifteen phenolic compounds were characterized by ultra-high-performance liquid chromatography-ultraviolet detection-mass spectrometry analysis, from which two flavan-3-ols, an acetophenone, five flavanones, and a flavonol were detected, for the first time, as their bark components. Salix bark extracts demonstrated strong free radical scavenging activity (5.58-23.62 mu g mL(-1) IC50 range), effective inhibition on angiotensin-I converting enzyme (58-84%), and S. aureus bactericidal action at 1250-2500 mu g mL(-1) (6-8 log CFU mL(-1) reduction range). All tested Salix bark extracts did not show cytotoxic potential against Caco-2 cells, as well as S. atrocinerea Brot. and S. fragilis L. extracts at 625 and 1250 mu g mL(-1) against HaCaT and L929 cells. These valuable findings can pave innovative and safer food, nutraceutical, and/or cosmetic applications of Salix bark phenolic-containing fractions. |
publisher |
MDPI |
isbn |
2076-3921 |
year published |
2019 |
volume |
8 |
issue |
12 |
digital object identifier (doi) |
10.3390/antiox8120609 |
web of science category |
Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science & Technology |
subject category |
Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science & Technology |
unique article identifier |
WOS:000506633000042
|
ciceco authors
impact metrics
journal analysis (jcr 2019):
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journal impact factor |
5.014 |
5 year journal impact factor |
Not Available |
category normalized journal impact factor percentile |
87.941 |
dimensions (citation analysis):
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altmetrics (social interaction):
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