Polyoxometalate Composites in Cancer Therapy and Diagnostics
authors Guedes, G; Wang, SQ; Santos, HA; Sousa, FL
nationality International
journal EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
author keywords Polyoxometalates; Photothermal therapy; Radiotherapy; Theranostics; Sensors
keywords RESISTANT STAPHYLOCOCCUS-AUREUS; TUMOR MICROENVIRONMENT; ANTIBACTERIAL ACTIVITY; BLOOD-GLUCOSE; NANOMATERIALS; PLATFORM; RADIOSENSITIZATION; POLYOXOTUNGSTATE; RADIORESISTANCE; NANOSTRUCTURES
abstract Polyoxometalates (POMs) are metal-oxide inorganic clusters, mostly anionic, where the metal is usually a transition metal (such as V, W, or Mo). Owing to their great variety of structures and large range of molecular dimensions, POMs have attracted considerable attention over the years. The high solubility in water together with the extent of their redox chemistry make POMs and their composites very versatile materials that find many applications in the biomedical field such as drug delivery systems or anti-viral and anti-tumoural agents. While the antitumoural activity of POMs and their derivatives is well documented, their application in emergent cancer therapies has not been addressed. This review presents the application of POM-based composites as photothermal agents, radiosensitisers, and biosensors. The latest advances in the design of novel POM nanocomposites for cancer theranostics are also highlighted.
publisher WILEY-V C H VERLAG GMBH
issn 1434-1948
year published 2020
volume 2020
issue 22
beginning page 2121
ending page 2132
digital object identifier (doi) 10.1002/ejic.202000066
web of science category Chemistry, Inorganic & Nuclear
subject category Chemistry
unique article identifier WOS:000529643200001
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journal analysis (jcr 2019):
journal impact factor 2.529
5 year journal impact factor 2.284
category normalized journal impact factor percentile 65.556
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