The Quest for Phenolic Compounds from Macroalgae: A Review of Extraction and Identification Methodologies
authors Santos, SAO; Felix, R; Pais, ACS; Rocha, SM; Silvestre, AJD
nationality International
journal BIOMOLECULES
author keywords bioactive compounds; extraction; characterization; macroalgae; phenolic compounds; phlorotannins; mass spectrometry; seaweed
keywords SUPERCRITICAL-FLUID EXTRACTION; EDIBLE BROWN ALGA; MICROWAVE-ASSISTED EXTRACTION; MOLECULAR-WEIGHT POLYPHLOROGLUCINOLS; PRESSURIZED LIQUID EXTRACTION; SEAWEED HIMANTHALIA-ELONGATA; DEEP EUTECTIC SOLVENTS; FUCUS-VESICULOSUS L; ASCOPHYLLUM-NODOSUM; ECKLONIA-CAVA
abstract The current interest of the scientific community for the exploitation of high-value compounds from macroalgae is related to the increasing knowledge of their biological activities and health benefits. Macroalgae phenolic compounds, particularly phlorotannins, have gained particular attention due to their specific bioactivities, including antioxidant, antiproliferative, or antidiabetic. Notwithstanding, the characterization of macroalgae phenolic compounds is a multi-step task, with high challenges associated with their isolation and characterization, due to the highly complex and polysaccharide-rich matrix of macroalgae. Therefore, this fraction is far from being fully explored. In fact, a critical revision of the extraction and characterization methodologies already used in the analysis of phenolic compounds from macroalgae is lacking in the literature, and it is of uttermost importance to compile validated methodologies and discourage misleading practices. The aim of this review is to discuss the state-of-the-art of phenolic compounds already identified in green, red, and brown macroalgae, reviewing their structural classification, as well as critically discussing extraction methodologies, chromatographic separation techniques, and the analytical strategies for their characterization, including information about structural identification techniques and key spectroscopic profiles. For the first time, mass spectrometry data of phlorotannins, a chemical family quite exclusive of macroalgae, is compiled and discussed.
publisher MDPI
isbn 2218-273X
year published 2019
volume 9
issue 12
digital object identifier (doi) 10.3390/biom9120847
web of science category Biochemistry & Molecular Biology
subject category Biochemistry & Molecular Biology
unique article identifier WOS:000506636800096
  ciceco authors
  impact metrics
journal analysis (jcr 2019):
journal impact factor 4.082
5 year journal impact factor Not Available
category normalized journal impact factor percentile 67.172
dimensions (citation analysis):
altmetrics (social interaction):



 


Sponsors

1suponsers_list_ciceco.jpg