Ionic Liquids in Bioseparation Processes
authors Belchior, DCV; Duarte, IF; Freire, MG
editors Itoh, T; Koo, YM
nationality International
journal APPLICATION OF IONIC LIQUIDS IN BIOTECHNOLOGY
author keywords Amino acids; Ionic liquid; Liquid-liquid extraction; Proteins; Solid-liquid extraction
keywords AQUEOUS 2-PHASE SYSTEMS; SOLID-PHASE EXTRACTION; BOVINE SERUM-ALBUMIN; BIPHASIC SYSTEMS; AMINO-ACIDS; CYTOCHROME-C; PARTITIONING BEHAVIOR; 1-BUTYL-3-METHYLIMIDAZOLIUM BROMIDE; EFFECTIVE SEPARATION; ENHANCED EXTRACTION
abstract Bioseparation processes are a relevant part of modern biotechnology, particularly regarding the development of efficient and biocompatible methods for the separation and purification of added-value biologically active compounds. In this field, ionic liquids (ILs) have been proposed, either in liquid-liquid extractions, in which non-water miscible ILs or aqueous biphasic systems (ABS) formed by ILs can be used, or in solid-liquid extractions, in which they are covalently attached to create supported IL phases (SILPs). Aprotic ILs possess unique properties, such as non-volatility and designability, which are valuable in their use in bioseparation processes. In this chapter, we summarize and discuss bioseparation processes based on ILs, including both liquid-liquid and solid-liquid extractions, applied to amino acids and proteins. The most recent and remarkable advances in this area are emphasized, and improvements brought by the use of ILs properly discussed. New insights and envisaged directions with IL-based bioseparation processes are suggested. [GRAPHICS] .
publisher SPRINGER INTERNATIONAL PUBLISHING AG
issn 0724-6145
isbn 1616-8542
year published 2019
volume 168
beginning page 1
ending page 29
digital object identifier (doi) 10.1007/10_2018_66
book digital object identifier (doi) 10.1007/978-3-030-23081-4
web of science category Biotechnology & Applied Microbiology; Engineering, Chemical
subject category Biotechnology & Applied Microbiology; Engineering
unique article identifier WOS:000501492500002

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