A polynuclear Cu(ii) complex for real time monitoring of mitochondrial cytochromeCrelease during cellular apoptosis
authors Khanra, S; Ta, S; Paladhi, A; Ghosh, M; Ghosh, S; Hira, SK; Manna, PP; Brandao, P; Felix, V; Das, D
nationality International
journal CHEMICAL COMMUNICATIONS
abstract A new amide-imine conjugate, 2-hydroxybenzoic acid-(2-hydroxybenzylidene)-hydrazide (L-1), is employed to prepare a single crystal X-ray structurally characterized poly-nuclear Cu(ii) complex (M1). M1 selectively and spatially interacts with cytochromeC(CytC) to allow fluorescence imaging of intracellular translocation events in living cells. Thus, direct visualization of a CytCtranslocation event during an apoptotic process is achieved for the first time. The binding constant and LOD are 7.52 x 10(4)M(-1)and 34.0 nM, respectively.
publisher ROYAL SOC CHEMISTRY
issn 1359-7345
isbn 1364-548X
year published 2020
volume 56
issue 48
beginning page 6563
ending page 6566
digital object identifier (doi) 10.1039/d0cc01606c
web of science category Chemistry, Multidisciplinary
subject category Chemistry
unique article identifier WOS:000544281500019
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journal impact factor 5.996
5 year journal impact factor 5.818
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