Cell Encapsulation Systems Toward Modular Tissue Regeneration: From Immunoisolation to Multifunctional Devices
authors Correia, CR; Nadine, S; Mano, JF
nationality International
journal ADVANCED FUNCTIONAL MATERIALS
author keywords cell encapsulation; hydrogels; immunomodulation; tissue regeneration
keywords MESENCHYMAL STEM-CELLS; STRUCTURED SUPERHYDROPHOBIC SURFACES; ENGINEERED HEART-TISSUE; FOREIGN-BODY RESPONSE; HYALURONIC-ACID; EXTRACELLULAR-MATRIX; ALGINATE HYDROGEL; IN-VITRO; IMMUNOMODULATORY PROPERTIES; COMPARTMENTALIZED CAPSULES
abstract In the primordial cell encapsulation systems, the main goal is to treat endocrine diseases avoiding the action of the immune system. Although lessons afforded by such systems are of outmost importance for the demands of tissue engineering and regenerative medicine, the paradigm has recently completely changed. If before the most important feature was to mask the encapsulated cells from the immune system, now it is known that the synergetic interplay between immune cells and the engineered niche is responsible for an adequate regenerative process. Combined with such immuno-awareness, novel or nonconventional emerging techniques are being proposed to develop the new generation of cell encapsulation systems, namely layer-by-layer, microfluidics, superhydrophobic surfaces, and bioprinting technologies. Alongside the desire to create more realistic cell encapsulation systems, cell-laden hydrogels are being explored as building blocks for bottom-up strategies, within the concept of modular tissue engineering. The idea is to use the well-established cell-friendly environment provided by hydrogels and create more close-to-native systems that possess high heterogeneity, while providing multifunctional and adaptive inputs.
publisher WILEY-V C H VERLAG GMBH
issn 1616-301X
isbn 1616-3028
year published 2020
volume 30
issue 26
digital object identifier (doi) 10.1002/adfm.201908061
web of science category Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter
subject category Chemistry; Science & Technology - Other Topics; Materials Science; Physics
unique article identifier WOS:000510966300001
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journal analysis (jcr 2019):
journal impact factor 16.836
5 year journal impact factor 15.722
category normalized journal impact factor percentile 95.322
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