Dehydropeptide-based plasmonic magnetogels: a supramolecular composite nanosystem for multimodal cancer therapy
authors Veloso, SRS; Martins, JA; Hilliou, L; Amorim, CO; Amaral, VS; Almeida, BG; Jervis, PJ; Moreira, R; Pereira, DM; Coutinho, PJG; Ferreira, PMT; Castanheira, EMS
nationality International
journal JOURNAL OF MATERIALS CHEMISTRY B
keywords NONSTEROIDAL ANTIINFLAMMATORY DRUG; MANGANESE FERRITE NANOPARTICLES; GOLD NANOPARTICLES; NONLINEAR ELASTICITY; CIRCULAR-DICHROISM; OPTICAL-PROPERTIES; QUANTUM YIELDS; HYDROGELS; FLUORESCENCE; SIZE
abstract Supramolecular hydrogels are highly promising candidates as biomedical materials owing to their wide array of properties, which can be tailored and modulated. Additionally, their combination with plasmonic/magnetic nanoparticles to form plasmonic magnetogels further improves their potential in biomedical applications through the combination of complementary strategies, such as photothermia, magnetic hyperthermia, photodynamic therapy and magnetic-guided drug delivery. Here, a new dehydropeptide hydrogelator, Npx-l-Met-Z-Delta Phe-OH, was developed and combined with two different plasmonic/magnetic nanoparticle architectures, i.e., core/shell manganese ferrite/gold nanoparticles and gold-decorated manganese ferrite nanoparticles with ca. 55 nm and 45 nm sizes, respectively. The magnetogels were characterized via HR-TEM, FTIR spectroscopy, circular dichroism and rheological assays. The gels were tested as nanocarriers for a model antitumor drug, the natural compound curcumin. The incorporation of the drug in the magnetogel matrices was confirmed through fluorescence-based techniques (FRET, fluorescence anisotropy and quenching). The curcumin release profiles were studied with and without the excitation of the gold plasmon band. The transport of curcumin from the magnetogels towards biomembrane models (small unilamellar vesicles) was assessed via FRET between the fluorescent drug and the lipid probe Nile Red. The developed magnetogels showed promising results for photothermia and photo-triggered drug release. The magnetogels bearing gold-decorated nanoparticles showed the best photothermia properties, while the ones containing core/shell nanoparticles had the best photoinduced curcumin release.
publisher ROYAL SOC CHEMISTRY
issn 2050-750X
isbn 2050-7518
year published 2020
volume 8
issue 1
beginning page 45
ending page 64
digital object identifier (doi) 10.1039/c9tb01900f
web of science category Materials Science, Biomaterials
subject category Materials Science
unique article identifier WOS:000503484700003
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journal analysis (jcr 2019):
journal impact factor 5.344
5 year journal impact factor 5.022
category normalized journal impact factor percentile 77.632
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