Monitoring Proteolytic Activity in Real Time: A New World of Opportunities for Biosensors
authors Oliveira-Silva, R; Sousa-Jeronimo, M; Botequim, D; Silva, NJO; Paulo, PMR; Prazeres, DMF
nationality International
journal TRENDS IN BIOCHEMICAL SCIENCES
keywords PROTEASE ACTIVITY; METALLOPROTEINASES; INHIBITORS; SYSTEM; PROBE
abstract Proteases play a pivotal role in several biological processes, from digestion, cell proliferation, and differentiation to fertility. Deregulation of protease metabolism can result in several pathological conditions (i.e., cancer, neurodegenerative disorders, and others). Therefore, monitoring proteolytic activity in real time could have a fundamental role in the early diagnosis of these diseases. Herein, the main approaches used to develop biosensors for monitoring proteolytic activity are reviewed. A comparison of the advantages and disadvantages of each approach is provided along with a discussion of their importance and promising opportunities for the early diagnosis of severe diseases. This new era of biosensors can be characterized by the ability to control and monitor biological processes, ultimately improving the potential of personalized medicine.
publisher ELSEVIER SCIENCE LONDON
issn 0968-0004
year published 2020
volume 45
issue 7
beginning page 604
ending page 618
digital object identifier (doi) 10.1016/j.tibs.2020.03.011
web of science category Biochemistry & Molecular Biology
subject category Biochemistry & Molecular Biology
unique article identifier WOS:000540873500008
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journal analysis (jcr 2019):
journal impact factor 14.732
5 year journal impact factor 17.932
category normalized journal impact factor percentile 97.811
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