Natural and Biomimetic Antitumor Pyrazoles, A Perspective
authors Santos, NE; Carreira, ARF; Silva, VLM; Braga, SS
nationality International
journal MOLECULES
author keywords pyrazole alkaloids; pyrazofurin; dystamycin analogues; curcuminoid pyrazoles
keywords HYBRID MOLECULES; BIOLOGICAL EVALUATION; ALKALOIDS; PRODUCTS; 1,2-DIAZOLE; DISTAMYCIN; DESIGN; FUTURE; PHASE
abstract The present review presents an overview of antitumor pyrazoles of natural or bioinspired origins. Pyrazole compounds are relatively rare in nature, the first ones having been reported in 1966 and being essentially used as somniferous drugs. Cytotoxic pyrazoles of natural sources were first isolated in 1969, and a few others have been reported since then, most of them in the last decade. This paper presents a perspective on the current knowledge on antitumor natural pyrazoles, organized into two sections. The first focuses on the three known families of cytotoxic pyrazoles that were directly isolated from plants, for which the knowledge of the medicinal properties is in its infancy. The second section describes pyrazole derivatives of natural products, discussing their structure-activity relationships.
publisher MDPI
isbn 1420-3049
year published 2020
volume 25
issue 6
digital object identifier (doi) 10.3390/molecules25061364
web of science category Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
subject category Biochemistry & Molecular Biology; Chemistry
unique article identifier WOS:000530248700107
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journal analysis (jcr 2019):
journal impact factor 3.267
5 year journal impact factor 3.589
category normalized journal impact factor percentile 56.714
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