Role of active nanoliposomes in the surface and bulk mechanical properties of hybrid hydrogels
authors Kadri, R; Bacharouch, J; Elkhoury, K; Ben Messaoud, G; Kahn, C; Desobry, S; Linder, M; Tamayol, A; Francius, G; Mano, JF; Sanchez-Gonzalez, L; Arab-Tehrany, E
nationality International
journal MATERIALS TODAY BIO
author keywords Liposomes; GelMA; Alginate; IPN hydrogels; Nanofunctionalization
keywords NANOCOMPOSITE HYDROGELS; NETWORK; POLYSACCHARIDES; NANOPARTICLES; DRESSINGS; POLYMERS; MEDICINE
abstract Nanoliposomes are widely used as delivery vehicles for active compounds. Nanoliposomes from rapeseed phospholipids were incorporated into interpenetrating polymer network hydrogels of gelatin methacryloyl and alginate. The multiscale physicochemical properties of the hydrogels are studied both on the surface and through the thickness of the 3D network. The obtained composite hydrogels exhibited strong mechanical properties and a highly porous surface. The blend ratio, as well as the concentration of nanoliposomes, affects the properties of the hydrogels. Nanofunctionalized hydrogels induced keratinocyte growth. These advantageous characteristics may open up many applications of the developed hydrogels in drug delivery and tissue engineering.
publisher ELSEVIER
issn 2590-0064
year published 2020
volume 6
digital object identifier (doi) 10.1016/j.mtbio.2020.100046
web of science category Engineering, Biomedical; Materials Science, Biomaterials
subject category Engineering; Materials Science
unique article identifier WOS:000546333300003

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