Stealth Magnetoliposomes Based on Calcium-Substituted Magnesium Ferrite Nanoparticles for Curcumin Transport and Release
authors Cardoso, BD; Rodrigues, ARO; Almeida, BG; Amorim, CO; Amaral, VS; Castanheira, EMS; Coutinho, PJG
nationality International
journal INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
author keywords magnetic nanoparticles; calcium-substituted magnesium ferrites; magnetoliposomes; curcumin release; cancer therapy
keywords MAGNETITE NANOPARTICLES; QUANTUM YIELDS; LIPID-BILAYER; IN-VITRO; FLUIDITY; PROTEINS; VESICLES; DELIVERY
abstract Despite the promising pharmacological properties of curcumin, the transport and effective release of curcumin is still a challenge. The advances in functionalized nanocarriers for curcumin have also been motivated by the anticancer activity of this natural compound, aiming at targeted therapies. Here, stealth (aqueous and solid) magnetoliposomes containing calcium-substituted magnesium ferrite nanoparticles, CaxMg1-xFe2O4 (with x = 0.25, 0.50, 0.75) were developed as nanocarriers for curcumin. The magnetic nanoparticles exhibit superparamagnetic properties and crystalline structure, with sizes below 10 nm. The magnetoliposomes based on these nanoparticles have hydrodynamic diameters around or below 150 nm and a low polydispersity. The influence of an alternating magnetic field (AMF) on drug release over time was evaluated and compared with curcumin release by diffusion. The results suggest the potential of drug-loaded magnetoliposomes as nanocarriers that can be magnetically guided to the tumor sites and act as agents for a synergistic effect combining magnetic hyperthermia and controlled drug release.
publisher MDPI
isbn 1422-0067
year published 2020
volume 21
issue 10
digital object identifier (doi) 10.3390/ijms21103641
web of science category Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
subject category Biochemistry & Molecular Biology; Chemistry
unique article identifier WOS:000539312100237
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journal analysis (jcr 2019):
journal impact factor 4.556
5 year journal impact factor 4.653
category normalized journal impact factor percentile 74.208
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