Unveiling the mechanism of hydrotropy: evidence for water-mediated aggregation of hydrotropes around the solute
authors Abranches, DO; Benfica, J; Soares, BP; Leal-Duaso, A; Sintra, TE; Pires, E; Pedro, SP; Shimizu, S; Coutinho, JAP
nationality International
journal CHEMICAL COMMUNICATIONS
keywords AQUEOUS-SOLUTIONS; SOLUBILIZATION; NICOTINAMIDE; DRUG; RIBOFLAVIN; STACKING; UREA
abstract A recent proposal attributes the origin of hydrotropy to the water-mediated aggregation of hydrotrope molecules around the solute. Experimental evidence for this phenomenon is reported for the first time in this work, using(1)H-NMR. A new computational technique to quantify apolarity is introduced and is used to show that apolarity of both solute and hydrotrope is the driving force of hydrotropy.
publisher ROYAL SOC CHEMISTRY
issn 1359-7345
year published 2020
volume 56
issue 52
beginning page 7143
ending page 7146
digital object identifier (doi) 10.1039/d0cc03217d
web of science category Chemistry, Multidisciplinary
subject category Chemistry
unique article identifier WOS:000544483800014
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journal analysis (jcr 2019):
journal impact factor 5.996
5 year journal impact factor 5.818
category normalized journal impact factor percentile 81.073
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