Functionalization of Graphene Oxide with Porphyrins: Synthetic Routes and Biological Applications
authors Monteiro, AR; Neves, MGPMS; Trindade, T
nationality International
journal CHEMPLUSCHEM
author keywords cancer; graphene oxide; hybrid composites; nanomaterials; porphyrinoids
keywords PHOTODYNAMIC THERAPY; GRAPHITE OXIDE; NANOGRAPHENE OXIDE; VANADIUM PENTOXIDE; DRUG-DELIVERY; SPECTROSCOPIC CHARACTERIZATION; ENVIRONMENTAL REMEDIATION; ELECTROCHEMICAL DETECTION; RADICAL POLYMERIZATION; PHOTOTHERMAL THERAPY
abstract Among the available carbon nanomaterials, graphene oxide (GO) has been widely studied because of the possibility of anchoring different chemical species for a large number of applications, including those requiring water-compatible systems. This Review summarizes the state-of-the-art of synthetic routes used to functionalize GO, such as those involving multiple covalent and non-covalent bonds to organic molecules, functionalization with nanoparticles and doping. As a recent development in this field, special focus is given to the formation of nanocomposites comprising GO and porphyrins, and their characterization through spectroscopic techniques (such as UV-Vis, fluorescence, Raman spectroscopy), among others. The potential of such hybrid systems in targeted biological applications is also discussed, namely for cancer therapies relying on photodynamic and photothermal therapies and for the inhibition of telomerase enzyme. Lastly, some promising alternative materials to GO are presented to overcome current challenges of GO-based research and to inspire future research directions in this field.
publisher WILEY-V C H VERLAG GMBH
issn 2192-6506
year published 2020
volume 85
issue 8
beginning page 1857
ending page 1880
digital object identifier (doi) 10.1002/cplu.202000455
web of science category Chemistry, Multidisciplinary
subject category Chemistry
unique article identifier WOS:000563997000027
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journal analysis (jcr 2019):
journal impact factor 2.753
5 year journal impact factor 2.723
category normalized journal impact factor percentile 53.39
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