Spray-dried hydroxyapatite-5-Fluorouracil granules as a chemotherapeutic delivery system
authors Santos, C; Rovath, CF; Franke, RP; Almeida, MM; Costa, MEV
nationality International
journal CERAMICS INTERNATIONAL
author keywords Spray drying; Drug delivery; Hydroxyapatite; 5-Fluorouracil
keywords HYDROXYAPATITE PARTICLES; RELEASE; NANOPARTICLES
abstract This study describes the preparation and characterization of hydroxyapatite-5-Fluorouracil (5FU) granules, which are intended to be used as chemotherapeutic delivery matrices and bone regeneration templates. Suspensions of hydroxyapatite (Hap) nanoparticles in 5FU solution are spray dried as micro sized granules having donut type shape. Several spray drying temperatures are studied 80 degrees C being the optimized condition for obtaining granules composed by Hap and 5FU without secondary phases. The produced granules at 80 degrees C reveal a fast releasing rate of 5FU when soaked in buffer phosphate solution maintained at physiological temperature (37 degrees C, thereby indicating the potential application of the produced Hap matrices for drug delivery systems (DDSs). (C) 2008 Elsevier Ltd and Techna Group S.r.l. All rights reserved.
publisher ELSEVIER SCI LTD
issn 0272-8842
year published 2009
volume 35
issue 1
beginning page 509
ending page 513
digital object identifier (doi) 10.1016/j.ceramint.2008.01.012
web of science category Materials Science, Ceramics
subject category Materials Science
unique article identifier WOS:000261818300086
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journal analysis (jcr 2017):
journal impact factor 3.057
5 year journal impact factor 2.882
category normalized journal impact factor percentile 94.444
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