Biofunctionalized magnetic hydrogel nanospheres of magnetite and kappa-carrageenan
authors Daniel-da-Silva, AL; Fateixa, S; Guiomar, AJ; Costa, BFO; Silva, NJO; Trindade, T; Goodfellow, BJ; Gil, AM
nationality International
journal NANOTECHNOLOGY
keywords DIFFERENTIAL SCANNING CALORIMETRY; IRON-OXIDE NANOPARTICLES; MINIEMULSION POLYMERIZATION; BIOMEDICAL APPLICATIONS; STARCH DERIVATIVES; DRUG-DELIVERY; PARTICLES; FUNCTIONALIZATION; CARBOXYMETHYLATION; MICROGELS
abstract Magnetic hydrogel kappa-carrageenan nanospheres were successfully prepared via water-in-oil (w/o) microemulsions combined with thermally induced gelation of the polysaccharide. The size of the nanospheres (an average diameter (empty set) of about 50 and 75 nm) was modulated by varying the concentration of surfactant. The nanospheres contained superparamagnetic magnetite nanoparticles (empty set 8 nm), previously prepared by co-precipitation within the biopolymer. Carboxyl groups, at a concentration of about 4 mmol g(-1), were successfully grafted at the surface of these magnetic nanospheres via carboxymethylation of the kappa-carrageenan. The carboxylated nanospheres were shown to be thermo-sensitive in the 37-45 degrees C temperature range, indicating their potential as thermally controlled delivery systems for drugs and/or magnetic particles at physiological temperatures. Finally, preliminary results have been obtained for IgG antibody conjugation of the carboxylated nanospheres and the potential of these systems for bio-applications is discussed.
publisher IOP PUBLISHING LTD
issn 0957-4484
year published 2009
volume 20
issue 35
digital object identifier (doi) 10.1088/0957-4484/20/35/355602
web of science category Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied
subject category Science & Technology - Other Topics; Materials Science; Physics
unique article identifier WOS:000268911500014
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journal impact factor 3.404
5 year journal impact factor 3.467
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