Tailoring the morphology of high molecular weight PLLA scaffolds through bioglass addition
authors Barroca, N; Daniel-da-Silva, AL; Vilarinho, PM; Fernandes, MHV
nationality International
journal ACTA BIOMATERIALIA
author keywords Poly(L-lactic) acid; Thermally induced phase separation; Bioactive glass; Crystallinity; Porosity
keywords INDUCED PHASE-SEPARATION; MACROPOROUS POLY(L-LACTIDE) SCAFFOLD; IN-VITRO BIOACTIVITY; COMPOSITE SCAFFOLDS; POLYMERIC SCAFFOLDS; GLASS COMPOSITES; ACID) SCAFFOLDS; BONE; SYSTEM; FABRICATION
abstract Thermally induced phase separation (TIPS) has proven to be a suitable method for the preparation of porous structures for tissue engineering applications, and particular attention has been paid to increasing the pore size without the use of possible toxic surfactants. Within this context, an alternative method to control the porosity of polymeric scaffolds via the combination with a bioglass is proposed in this work. The addition of a bioactive glass from the 3CaO center dot P(2)O(5)-MgO-SiO(2) system enables the porous structure of high molecular weight poly(L-lactic) acid (PLLA) scaffolds prepared by TIPS to be tailored. Bioglass acts as a nucleating catalyst agent of the PLLA matrix, promoting its crystallization, and the glass solubility controls the pore size. A significant increase in the pore size is observed as the bioglass content increases and scaffolds with large pore size (similar to 150 mu m) can be prepared. In addition, the bioactive character of the scaffolds is proved by in vitro tests in synthetic plasma. The importance of this approach resides on the combination of the ability to tailor the porosity of polymeric scaffolds via the tunable solubility of bioglasses, without the use of toxic surfactants, leading to a composite structure with suitable properties for bone tissue engineering applications. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
publisher ELSEVIER SCI LTD
issn 1742-7061
year published 2010
volume 6
issue 9
beginning page 3611
ending page 3620
digital object identifier (doi) 10.1016/j.actbio.2010.03.032
web of science category Engineering, Biomedical; Materials Science, Biomaterials
subject category Engineering; Materials Science
unique article identifier WOS:000281318400028
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journal analysis (jcr 2017):
journal impact factor 6.383
5 year journal impact factor 7.160
category normalized journal impact factor percentile 93.969
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