Fine Tuning of the Relaxometry of gamma-Fe2O3@SiO2 Nanoparticles by Tweaking the Silica Coating Thickness
authors Pinho, SLC; Pereira, GA; Voisin, P; Kassem, J; Bouchaud, V; Etienne, L; Peters, JA; Carlos, LD; Mornet, S; Geraldes, CFGC; Rocha, J; Delville, MH
nationality International
journal ACS NANO
author keywords iron oxide nanoparticles; silica coating; NMR relaxation rates; MRI contrast agents
keywords IRON-OXIDE NANOPARTICLES; CDSE/CDS CORE/SHELL NANOCRYSTALS; NMR TRANSVERSAL RELAXIVITY; SEMICONDUCTOR QUANTUM DOTS; MAGNETIC NANOPARTICLES; FE3O4 NANOPARTICLES; CONTROLLED GROWTH; CONTRAST AGENTS; PARTICLES; CELLS
abstract We report the fine-tuning of the relaxometry of gamma-Fe2O3@SiO2 core-shell nanoparticles by adjusting the thickness of the coated silica layer. It is clear that the coating thickness of gamma Fe2O3@SiO2 nanoparticles has a significant impact on the r(1) (at low B-0 fields), r(2), and r(2)* relaxivities of their aqueous suspensions. These studies clearly indicate that the silica layer is heterogeneous and has regions that are porous to water and others that are not. It is also shown, that the viability and the mitochondrial dehydrogenase expression of the microglial cells do not appear to be sensitive to the vesicular load with these core shell nanoparticles. The adequate silica shell thickness can therefore be tuned to allow for both a sufficiently high response as contrast agent, and adequate grafting of targeted biomolecules.
publisher AMER CHEMICAL SOC
issn 1936-0851
year published 2010
volume 4
issue 9
beginning page 5339
ending page 5349
digital object identifier (doi) 10.1021/nn101129r
web of science category Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
subject category Chemistry; Science & Technology - Other Topics; Materials Science
unique article identifier WOS:000282121000048
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journal impact factor 13.709
5 year journal impact factor 14.820
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