New titanium and titanium/hydroxyapatite coatings on ultra-high-molecular-weight polyethylene-in vitro osteoblastic performance
authors Silva, MA; Gomes, PS; Vila, M; Lopes, MA; Santos, JD; Silva, RF; Fernandes, MH
nationality International
journal BIOMEDICAL MATERIALS
keywords TOTAL HIP-ARTHROPLASTY; ACETABULAR FIXATION OPTIONS; CALCIUM-PHOSPHATE COATINGS; BIOLOGICAL EVALUATION; BONE-CEMENT; SURFACE; COMPONENTS; WEAR
abstract The development of optimized hip joint materials is one of the most challenging opportunities in prosthetic technologies. In current approaches, ultra-high-molecular-weight polyethylene (UHMWPE) has been a favorite material for the acetabular component and, regarding the cementless technique, several coating options may be considered to contain and stabilize bearing surfaces and establish an improved interface with bone. In this work, newly developed constructs of UHMWPE coated with either commercially pure titanium (cpTi-UHMWPE), by DC magnetron sputtering, or with commercially pure titanium and hydroxyapatite (cpTi/HA-UHMWPE), by DC/RF magnetron co-sputtering, have been prepared and biologically characterized with human bone marrow-derived osteoblastic cultures. The cpTi-UHMWPE samples allowed a high cell growth and the expression of the complete osteoblastic phenotype, with high alkaline phosphatase activity, expression of osteogenic-associated genes and evident cell-mediated mineralization of the extracellular matrix. In comparison, the cpTi/HA-UHMWPE samples reported lower cell proliferation but earlier cell-mediated matrix mineralization. Accordingly, these newly developed systems may be suitable candidates to improve the osteointegration process in arthroplastic devices; nevertheless, further biological evaluation should be conducted.
publisher IOP PUBLISHING LTD
issn 1748-6041
year published 2010
volume 5
issue 3
digital object identifier (doi) 10.1088/1748-6041/5/3/035014
web of science category Engineering, Biomedical; Materials Science, Biomaterials
subject category Engineering; Materials Science
unique article identifier WOS:000278408500014
  ciceco authors
  impact metrics
times cited (wos core): 5
journal impact factor (jcr 2016): 2.469
5 year journal impact factor (jcr 2016): 2.947
category normalized journal impact factor percentile (jcr 2016): 53.247
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