Synthesis and swelling behavior of temperature responsive kappa-carrageenan nanogels
authors Daniel-da-Silva, AL; Ferreira, L; Gil, AM; Trindade, T
nationality International
journal JOURNAL OF COLLOID AND INTERFACE SCIENCE
author keywords Nanogels; kappa-Carrageenan; Thermoresponsive; Controlled drug delivery
keywords DRUG-DELIVERY APPLICATIONS; SUSTAINED-RELEASE CARRIERS; GELATIN NANOPARTICLES; THERMOSENSITIVE NANOPARTICLES; MICROEMULSIONS
abstract Crosslinked kappa-carrageenan hydrogel nanoparticles (nanogels) with an average size smaller than 100 nm were prepared using reverse microemulsions combined with thermally induced gelation. The size of the nanogels varied with biopolymer concentration at a constant water/surfactant concentration ratio. The nanogels were found to be thermo-sensitive in a temperature range acceptable for living cells (37-45 degrees C) undergoing reversible volume transitions in response to thermal stimuli. This opens the possibility to explore the application of these nanogels in smart therapeutics such as thermo-sensitive drug carriers. As such, the sustained release of methylene blue from the nanogels was evaluated in in vitro conditions as proof of concept experiments and the release rate was found to be controlled with temperature. (C) 2010 Elsevier Inc. All rights reserved.
publisher ACADEMIC PRESS INC ELSEVIER SCIENCE
issn 0021-9797
year published 2011
volume 355
issue 2
beginning page 512
ending page 517
digital object identifier (doi) 10.1016/j.jcis.2010.12.071
web of science category Chemistry, Physical
subject category Chemistry
unique article identifier WOS:000287335300034
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journal analysis (jcr 2017):
journal impact factor 5.091
5 year journal impact factor 4.281
category normalized journal impact factor percentile 77.891
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