Photoluminescence, cytotoxicity and in vitro imaging of hexagonal terbium phosphate nanoparticles doped with europium
authors Di, WH; Li, J; Shirahata, N; Sakka, Y; Willinger, MG; Pinna, N
nationality International
journal NANOSCALE
keywords NANOCRYSTALS; MORPHOLOGY; NANOWIRES; NANORODS; PROBES
abstract Luminescent TbPO4 nanoparticles were synthesized via a citric-acid-mediated hydrothermal route. Eu3+ doping of TbPO4 enables an efficient Tb3+-to-Eu3+ energy transfer, leading to a four-fold increase of the absolute emission quantum yield (QY), compared to that of undoped TbPO4. To check the potential of biological use, we conducted in vitro biological experiments on human cervical carcinoma HeLa cells incubated with TbPO4:Eu nanoparticles. TbPO4:Eu nanoparticles can be successfully internalized into the cells, and they show bright intracellular luminescence and very low cytotoxicity. Photoluminescence intensity dependence upon time demonstrates that Eu3+-doped TbPO4 nanoparticles are highly resistant to photobleaching. Our present work represents a demonstration of the use of rare-earth-based nanocrystals as a biological labeling agent because they combine several advantages including high emission quantum yield, long luminescence lifetime, low cytotoxicity and high photostability.
publisher ROYAL SOC CHEMISTRY
issn 2040-3364
year published 2011
volume 3
issue 3
beginning page 1263
ending page 1269
digital object identifier (doi) 10.1039/c0nr00673d
web of science category Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied
subject category Chemistry; Science & Technology - Other Topics; Materials Science; Physics
unique article identifier WOS:000288218300070
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  impact metrics
journal impact factor (jcr 2016): 7.367
5 year journal impact factor (jcr 2016): 7.668
category normalized journal impact factor percentile (jcr 2016): 89.149
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