Isolation, crystal structure, and cytotoxicity on osteosarcoma of a ruthenium(III) complex with coordinated acetonitrile
authors Marques, J; Fernandes, JA; Paz, FAA; Marques, MPM; Braga, SS
nationality International
journal JOURNAL OF COORDINATION CHEMISTRY
author keywords Ruthenium trithiacyclononane complexes; Acetonitrile; Single-crystal X-ray diffraction; Cytotoxicity evaluation
keywords DNA-BINDING; NAMI-A; DRUGS
abstract The precursor Ru([9]aneS(3))(DMSO)Cl-2 (1), where [9] aneS3 represents 1,4,7-trithiacyclononane, was dissolved in acetonitrile at 50 degrees C and stirred for several hours to assess the solvent's ability to coordinate to 1. A bis(acetonitrile) Ru(III) compound (2) crystallized as solid yellow needles upon slow evaporation of the reaction solution at room temperature. The structure of 2 was investigated in the solid state by FT-IR and single-crystal diffraction, showing it to be [Ru(III)([9]aneS(3))(NCMe)(2)Cl]Cl-2 center dot 2H(2)O (2). To assess the biological action of 2, growth-inhibition tests were carried by the MTT assay on a human tumor cell line of interest to our group, the osteosarcoma MG-63 line. Results have shown that the complex requires concentrations above 200 mu mol L-1 at 72 h of incubation to display cytotoxic action on this cell line.
publisher TAYLOR & FRANCIS LTD
issn 0095-8972
year published 2012
volume 65
issue 14
beginning page 2489
ending page 2499
digital object identifier (doi) 10.1080/00958972.2012.696624
web of science category Chemistry, Inorganic & Nuclear
subject category Chemistry
unique article identifier WOS:000305243900006
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journal impact factor 1.703
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