Bioinspired Antimicrobial and Biocompatible Bacterial Cellulose Membranes Obtained by Surface Functionalization with Aminoalkyl Groups
authors Fernandes, SCM; Sadocco, P; Aonso-Varona, A; Palomares, T; Eceiza, A; Silvestre, AJD; Mondragon, I; Freire, CSR
nationality International
journal ACS APPLIED MATERIALS & INTERFACES
author keywords bacterial cellulose; aminoalkyl groups; antimicrobial; biocompatibility
keywords ANTIBACTERIAL ACTIVITY; COUPLING AGENTS; CHITOSAN; FIBERS; PROTEINS; CELLS; FILMS
abstract There has been a great deal of interest in the use of nanostructured bacterial cellulose membranes for biomedical applications, including tissue implants, wound healing, and drug delivery. However, as bacterial cellulose does not intrinsically present antimicrobial properties, in the present study, antimicrobial bacterial cellulose membranes were obtained by chemical grafting of aminoalkyl groups onto the surface of its nanofibrillar network. This approach intends to mimic intrinsic antimicrobial properties of chitosan. Interestingly, these novel grafted bacterial cellulose membranes (BC-NH2) are simultaneously lethal against S. aureus and E. coli and nontoxic to human adipose-derived mesenchymal stem cells (ADSCs) and thus may be useful for biomedical applications. In addition to these biological properties, the bioactive nanostructured BC-NH2 membranes also present improved mechanical and thermal properties.
publisher AMER CHEMICAL SOC
issn 1944-8244
year published 2013
volume 5
issue 8
beginning page 3290
ending page 3297
digital object identifier (doi) 10.1021/am400338n
web of science category Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
subject category Science & Technology - Other Topics; Materials Science
unique article identifier WOS:000318205000063
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  impact metrics
journal analysis (jcr 2017):
journal impact factor 8.097
5 year journal impact factor 8.284
category normalized journal impact factor percentile 87.646
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