Synthesis of Unsymmetrical Methylenebisphenol Derivatives
authors Guieu, S; Rocha, J; Silva, AMS
nationality International
journal SYNLETT
author keywords benzylation; phenols; regioselectivity; methylenebisphenyls
keywords PTP1B INHIBITORS
abstract A simple and efficient route towards unsymmetrical methylenebisphenol derivatives is reported. This straightforward strategy avoids the use of harmful or dangerous chemicals, allowing the synthesis of highly functionalized bisphenyls with no need of protecting groups. The alkylation of the phenyl ring is selective for the para position of the hydroxyl substituent. All methylenebisphenols were obtained in a completely regioselective manner and isolated in high yields.
publisher GEORG THIEME VERLAG KG
issn 0936-5214
year published 2013
volume 24
issue 6
beginning page 762
ending page 764
digital object identifier (doi) 10.1055/s-0032-1318394
web of science category Chemistry, Organic
subject category Chemistry
unique article identifier WOS:000317956600018
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  impact metrics
journal analysis (jcr 2017):
journal impact factor 2.369
5 year journal impact factor 2.018
category normalized journal impact factor percentile 58.772
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