Solution studies on binary and ternary complexes of copper(II) with some fluoroquinolones and 1,10-phenanthroline: Antimicrobial activity of ternary metalloantibiotics
authors Gameiro, P; Rodrigues, C; Baptista, T; Sousa, I; de Castro, B
journal INTERNATIONAL JOURNAL OF PHARMACEUTICS
author keywords fluoroquinolones; ternary complexes; distribution diagrams; antibacterial activity
keywords RAY STRUCTURAL CHARACTERIZATION; DNA GYRASE; CRYSTAL-STRUCTURE; TOPOISOMERASE-IV; QUINOLONE ANTIBACTERIALS; METAL COMPLEXATION; MECHANISM; INHIBITION; RESISTANCE; ANTIBIOTICS
abstract Interaction of norfloxacin and ofloxacin with copper(II) and copper(II)/phenanthroline has been studied in aqueous solution and the stability constants of the binary complexes Cu(II)/fluoroquinolone and of the ternary complexes Cu(II)/phenanthroline/fluoroquinolone have been determined by potentiometry and UV-vis spectrophotometry. The stability constants for the binary and ternary complexes of norfloxacin were always higher than those found for ofloxacin and comparing the values obtained for the binary and ternary species (Delta log K) it is possible to conclude that the ternary complexes are more stable than the binary ones, suggesting that an interaction occurs between the ligands in the ternary complexes. From the distribution diagrams it is possible to state that at physiological pH 7.4, the copper ternary complexes, are the main species in solution not only at the concentration used to determined the stability constants but also at the minimum inhibitory concentration. The antibacterial activity of these complexes, in different bacterial strains, was determined, at physiological pH, and the results obtain show that these ternary complexes may be good candidates as metalloantibiotics. (c) 2006 Elsevier B.V. All rights reserved.
publisher ELSEVIER SCIENCE BV
issn 0378-5173
year published 2007
volume 334
issue 01-fev
beginning page 129
ending page 136
digital object identifier (doi) 10.1016/j.ijpharm.2006.10.035
web of science category Pharmacology & Pharmacy
subject category Pharmacology & Pharmacy
unique article identifier WOS:000245774400016
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