Synthesis, characterization and antibacterial studies of a copper(II) lomefloxacin ternary complex
authors Fernandes, P; Sousa, I; Cunha-Silva, L; Ferreira, M; de Castro, B; Pereira, EF; Feio, MJ; Gameiro, P
journal JOURNAL OF INORGANIC BIOCHEMISTRY
author keywords Lomefloxacin; Fluoroquinolones; Metalloantibiotics; Bacterial resistance; Solution equilibria
keywords INTRAMOLECULAR STACKING INTERACTIONS; RAY STRUCTURAL CHARACTERIZATION; OUTER-MEMBRANE PROTEINS; ESCHERICHIA-COLI K-12; IN-VITRO; FLUOROQUINOLONE ANTIBACTERIALS; CRYSTAL-STRUCTURE; METAL-IONS; QUINOLONE ANTIBIOTICS; AQUEOUS-SOLUTION
abstract Solution behavior of lomefloxacin (lmx) complexes with copper(II) in the presence and absence of 1,10-phenanthroline (phen) was studied in aqueous solution, by potentiometry. The results obtained showed that under physiological conditions (micromolar concentration range and pH 7.4) only copper(II):lmx:phen ternary complexes are stable. Hence, a novel copper(II) ternary complex of lomefloxacin with the nitrogen donor heterocyclic ligand phen was synthesized and characterized by means of UV-visible and IR spectroscopy, elemental analysis and X-ray crystallography. In the synthesized complex (1), [Cu(lmx)(phen)(NO3)]center dot 5H(2)O, lmx acts as a bidentate ligand coordinating the metal cation, in its anionic form, through the carbonyl and carboxyl oxygens and phen coordinates through two N-atoms forming the equatorial plane of a distorted square-pyramidal geometry. The fifth ligand of the penta-coordinated Cu(II) center is occupied axially by an oxygen atom from the nitrate ion. Minimum inhibitory concentration (MIC) determinations of the complex and comparison with free lomefloxacin in various E. coli strains indicated that the Cu-complex is an antimicrobial which is as efficient as the free antibiotic but strongly suggest that the cell intake route of both species is different. Moreover, spectrophotometric stability studies suggest that the solution of the complex synthesized is considerably more photostable than the free fluoroquinolone supporting, therefore, the complex's suitability as a candidate for further biological testing in fluoroquinolone-resistant microorganisms with possible reduced side-effects. (C) 2013 Elsevier Inc. All rights reserved.
publisher ELSEVIER SCIENCE INC
issn 0162-0134
year published 2014
volume 131
beginning page 21
ending page 29
digital object identifier (doi) 10.1016/j.jinorgbio.2013.10.013
web of science category Biochemistry & Molecular Biology; Chemistry, Inorganic & Nuclear
subject category Biochemistry & Molecular Biology; Chemistry
unique article identifier WOS:000329682100004
link http://www.sciencedirect.com/science/article/pii/S016201341300281X
  ciceco authors
  impact metrics
journal analysis (jcr 2019):
journal impact factor 3.212
5 year journal impact factor 3.226
category normalized journal impact factor percentile 64.781
dimensions (citation analysis):
altmetrics (social interaction):



 


Apoio

1suponsers_list_ciceco.jpg