Solubility of Hesperetin in Mixed Solvents
authors Ferreira, O; Schroder, B; Pinho, SP
nationality International
journal JOURNAL OF CHEMICAL AND ENGINEERING DATA
keywords CRYSTALLIZING DRUG PHASE; PLUS WATER MIXTURES; ETHANOL; DELIVERY; (R,S)-HESPERETIN; TRANSFORMATION; TEMPERATURES; FLAVONOIDS; NARINGENIN; QUERCETIN
abstract The study of the solubility of important biomolecules such as flavonoids is essential to support the design of several separation processes in the food and pharmaceutical industries. Following our previous studies, new solubility data of hesperetin in the mixed solvents water + acetone, water + ethanol, and water + methanol were measured, at 298.2 K, by the isothermal shake-flask method. The results obtained show three solid-liquid phase diagrams with distinct features. Additionally, the solid crystals obtained from the solubility studies were analyzed by powder X-ray diffraction, infrared spectroscopy, and thermogravimetric analysis indicating that, depending on the mixed solvents composition, two different crystal structures of hesperetin, already described in the literature, can be obtained, corresponding either to the anhydrous or the monohydrate forms.
publisher AMER CHEMICAL SOC
issn 0021-9568
year published 2013
volume 58
issue 9
beginning page 2616
ending page 2621
digital object identifier (doi) 10.1021/je400513s
web of science category Thermodynamics; Chemistry, Multidisciplinary; Engineering, Chemical
subject category Thermodynamics; Chemistry; Engineering
unique article identifier WOS:000330094400034
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journal analysis (jcr 2017):
journal impact factor 2.196
5 year journal impact factor 2.331
category normalized journal impact factor percentile 58.053
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