Synthesis, Characterisation and Antiproliferative Studies of Allyl(dicarbonyl)(cyclopentadienyl)molybdenum Complexes and Cyclodextrin Inclusion Compounds
authors Braga, SS; Mokal, V; Paz, FAA; Pillinger, M; Branco, AF; Sardao, VA; Diogo, CV; Oliveira, PJ; Marques, MPM; Romao, CC; Goncalves, IS
nationality International
journal EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
author keywords Molybdenum; Half-sandwich complexes; Cyclodextrins; Inclusion compounds; Antitumor agents
keywords ORGANOMETALLIC CONFORMATIONAL EQUILIBRIA; CAMBRIDGE STRUCTURAL DATABASE; RING INDENYL ANALOGS; BETA-CYCLODEXTRIN; CRYSTAL-STRUCTURES; ALLYL COMPLEXES; MIXED-RING; MOLYBDENUM COMPLEXES; CATALYST PRECURSORS; TUNGSTEN COMPLEXES
abstract The complexes [(eta(5)-C5H4-CO-R)Mo(CO)(2)(eta(3)-C3H5)] [R = OH (1), Phe OMe (2)] have been examined as guests for the cyclodextrin (CD) hosts beta-CD and heptakis(2,3,6-tri-O-methyl)-beta-CD (TRIMEB), and the resultant inclusion compounds have been characterised in the solid state by elemental and thermogravimetric analyses, powder X-ray diffraction, C-13{H-1) cross-polarisation (CP) magic angle spinning (MAS) NM R spectroscopy and ITTIR spectroscopy. Singlecrystal X-ray analysis of 1 shows that the unit cell contains centrosymmetric supramolecular dimers comprising two di- carlx)nyl complexes linked through hydrogen-bonding interactions involving the carboxylic acid groups. In screening tests for antiproliferative effects, the Cl) adducts containing 1 displayed enhanced antitumour activity against mouse melanoma (when compared with nonincluded 1), while showing minimal activity towards human adenocarcinoma and nontumour rat myoblast cell lines. TRIMEB encapsulation resulted in a predominant toxic effect on tumour cells versus the rion-neoplastic rriyoblasl cells.
publisher WILEY-V C H VERLAG GMBH
issn 1434-1948
year published 2014
issue 29
beginning page 5034
ending page 5045
digital object identifier (doi) 10.1002/ejic.201402540
web of science category Chemistry, Inorganic & Nuclear
subject category Chemistry
unique article identifier WOS:000343819200013
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