Azacalix[2]arene[2]triazine-based receptors bearing carboxymethyl pendant arms on nitrogen bridges: synthesis and evaluation of their coordination ability towards copper(II)
authors Caio, JM; Esteves, T; Carvalho, S; Moiteiro, C; Felix, V
nationality International
journal ORGANIC & BIOMOLECULAR CHEMISTRY
keywords SUPRAMOLECULAR CHEMISTRY; PI INTERACTIONS; TRIAZINE; MOLECULES; CAVITY; DERIVATIVES; COMPLEXES; SILICA
abstract For functional nitrogen-bridged calix(hetero)aromatic platforms to be further used in the design of more sophisticated receptors, the azacalix[2]arene[2]triazine nitrogen bridges were functionalised with methyl bromoacetate. Three new macrocycles with four N-methyl ester pendant arms were straightforwardly prepared in good yields from the undecorated azacalix[2]arene[2]triazine precursors with chlorine, dimethylamine or dihexylamine substituted triazines. These intermediate macrocycles exhibited different reactivity towards the nucleophilic replacement, which was rationalized from the computed electrostatic potential for these molecules. Subsequently, the N-methyl ester appendages were hydrolyzed with each dialkylamine derivative providing a single macrocycle with four carboxylic groups. In contrast the hydrolysis of the dichlorinated azacalix[2]arene[2]triazine analogue yielded a mixture of three isomeric macrocycles having two N-methyl esters and two carboxylmethyl pendant arms and the triazine chlorine atoms replaced by hydroxyl groups. The coordination ability of two macrocycles with four carboxylic groups for transition metals was evaluated with copper(II) by UV-vis titrations.
publisher ROYAL SOC CHEMISTRY
issn 1477-0520
year published 2014
volume 12
issue 4
beginning page 589
ending page 599
digital object identifier (doi) 10.1039/c3ob42047g
web of science category Chemistry, Organic
subject category Chemistry
unique article identifier WOS:000330082700007
link 24287688
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