CHARACTERIZATION OF THE TOXICOLOGICAL EFFECTS OF AMINOCARB ON RATS: HEMATOLOGICAL, BIOCHEMICAL, AND HISTOLOGICAL ANALYSES
authors Dias, E; Morais, S; Ramalheira, E; Pereira, ML
nationality International
journal JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
keywords CARBAMATE PESTICIDES; EXPOSURE; ORGANOPHOSPHORUS; INSECTICIDE
abstract Aminocarb is a widely applied carbamate insecticide with action of controlling pests such as Lepidoptera and Coleoptera. In this study, subchronic effects on Wistar rats were investigated using hematological, biochemical, and histological techniques. Rats were exposed orally at sublethal levels of 10, 20, or 40 mg/kg body weight (groups A, B, and C, respectively) for 14 d. Hematological results revealed no statistical differences after 1 d of exposure but significant reduction in white blood cells detected after 7 d of exposure in group C, as well as, in all treated groups after 14 d of exposure. Biochemical data showed a decrease of acetylcholinesterase activity in all groups after 1 d of exposure with a return to normal after 7 and 14 d. Significant increase in alkaline phosphatase activity of rats exposed to aminocarb was noted after 7 d of treatment. The levels of triglycerides were also significantly decreased. The present investigation also showed a significant increase in content of serum urea and creatinine in animals from group A (14 d), and from groups B and C (7 and 14 d). Histological results demonstrated hemorrhagic focus on hepatic and renal parenchyma in all exposed groups. Taken together, the attained results were dose dependent and indicated adverse effects of aminocarb on hepatic and renal functions, as well as on immune responsiveness at sublethal tested doses.
publisher TAYLOR & FRANCIS INC
issn 1528-7394
year published 2014
volume 77
issue 14-16
beginning page 849
ending page 855
digital object identifier (doi) 10.1080/15287394.2014.909305
web of science category Environmental Sciences; Public, Environmental & Occupational Health; Toxicology
subject category Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology
unique article identifier WOS:000340278000007
link 25072717
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journal impact factor 2.706
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