Processing strategies for smart electroconductive carbon nanotube-based bioceramic bone grafts
authors Mata, D; Oliveira, FJ; Ferreira, NM; Araujo, RF; Fernandes, AJS; Lopes, MA; Gomes, PS; Fernandes, MH; Silva, RF
nationality International
journal NANOTECHNOLOGY
author keywords carbon nanotubes; ceramic matrix composite; reactive sintering; hot-pressing; electroconductive bone graft; in vitro osteocompatibility
keywords REINFORCED-HYDROXYAPATITE COMPOSITES; OSTEOBLAST-LIKE CELLS; MECHANICAL-PROPERTIES; ELECTRICAL-STIMULATION; IN-VITRO; DIFFERENTIATION; DENSIFICATION; PHASE; BIOMATERIALS; FABRICATION
abstract Electroconductive bone grafts have been designed to control bone regeneration. Contrary to polymeric matrices, the translation of the carbon nanotube (CNT) electroconductivity into oxide ceramics is challenging due to the CNT oxidation during sintering. Sintering strategies involving reactive-bed pressureless sintering (RB + P) and hot-pressing (HP) were optimized towards prevention of CNT oxidation in glass/hydroxyapatite (HA) matrices. Both showed CNT retentions up to 80%, even at 1300 degrees C, yielding an increase of the electroconductivity in ten orders of magnitude relative to the matrix. The RB + P CNT compacts showed higher electroconductivity by similar to 170% than the HP ones due to the lower damage to CNTs of the former route. Even so, highly reproducible conductivities with statistical variation below 5% and dense compacts up to 96% were only obtained by HP. The hot-pressed CNT compacts possessed no acute toxicity in a human osteoblastic cell line. A normal cellular adhesion and a marked orientation of the cell growth were observed over the CNT composites, with a proliferation/differentiation relationship favouring osteoblastic functional activity. These sintering strategies offer new insights into the sintering of electroconductive CNT containing bioactive ceramics with unlimited geometries for electrotherapy of the bone tissue.
publisher IOP PUBLISHING LTD
issn 0957-4484
year published 2014
volume 25
issue 14
digital object identifier (doi) 10.1088/0957-4484/25/14/145602
web of science category Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied
subject category Science & Technology - Other Topics; Materials Science; Physics
unique article identifier WOS:000332942800012
link 24622290
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journal impact factor 3.404
5 year journal impact factor 3.467
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