Multifunctional Carbon Nanotube/Bioceramics Modulate the Directional Growth and Activity of Osteoblastic Cells
authors Mata, D; Oliveira, FJ; Ferro, M; Gomes, PS; Fernandes, MH; Lopes, MA; Silva, RF
nationality International
journal JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
author keywords Carbon Nanotubes; Ceramic-Matrix Composites; Powder Processing; Smart Materials; In Vitro Testing; Bone Tissue Engineering
keywords HUMAN CORTICAL BONE; SOLUBILITY PARAMETERS; ELECTROPHORETIC DEPOSITION; ORGANIC-SOLVENTS; PARTICLE-SIZE; IN-VITRO; NANOTUBES; TISSUE; FUNCTIONALIZATION; NANOCOMPOSITES
abstract Biomaterials can still be reinvented to become simple and universal bone regeneration solutions. Following this roadmap, a bone graft of carbon nanotube (CNT)/glass/hydroxyapatite (HA) with controlled CNT agglomeration state was designed with multifunctionalities able to stimulate the bone cell phenotype. The preparation route, the mechanical and electrical behavior and the in vitro profiles of degradation and osteocompatibility were described. A non-destructive dynamic route was found to have a higher influence than the Diels-Alder functionalization one on controlling the CNT agglomerate state in the ceramic-matrix composite. Biologically safe CNT agglomerates, with diameter sizes below 3 mu m homogenously distributed, were obtained in non-functionalized and functionalized composites. Yet, the lowest CNT damage and the highest mechanical and electrical properties were found for the non-functionalized materials. Even though that these composites present higher degradation rate at pH: 3 than the ceramic matrix, the CNT agglomerates are released with safe diameter sizes. Also, non-functionalized composites allowed cellular adhesion and modulated the orientation of the cell growth, with a proliferation/differentiation relationship favoring osteoblastic functional activity. Findings offer further contributions for bone tissue engineering by showing that multifunctional bone grafts with high electroconductivity, and integrating CNT agglomerates with maximized interfacing area, allow the in situ control of bone cell functions.
publisher AMER SCIENTIFIC PUBLISHERS
issn 1550-7033
year published 2014
volume 10
issue 5
beginning page 725
ending page 743
digital object identifier (doi) 10.1166/jbn.2014.1749
web of science category Nanoscience & Nanotechnology; Materials Science, Biomaterials
subject category Science & Technology - Other Topics; Materials Science
unique article identifier WOS:000327511400001
link 24734525
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journal analysis (jcr 2017):
journal impact factor 5.068
5 year journal impact factor 4.225
category normalized journal impact factor percentile 73.575
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