Recovery of paracetamol from pharmaceutical wastes
authors Silva, FAE; Sintra, T; Ventura, SPM; Coutinho, JAP
nationality International
journal SEPARATION AND PURIFICATION TECHNOLOGY
author keywords Pharmaceutical wastes; Active compounds; Paracetamol; Aqueous biphasic systems; Ionic liquid; Extraction efficiency
keywords AQUEOUS BIPHASIC SYSTEMS; HYDROPHOBIC IONIC LIQUIDS; 2-PHASE SYSTEMS; MUTUAL SOLUBILITIES; EXTRACTION SYSTEM; CLAVULANIC ACID; CONTROLLED PH; SALTS; WATER; FERMENTATION
abstract The concern about the impact of active pharmaceutical compounds on the environment has been growing for decades. This work looks at pharmaceutical wastes as a source of valuable active compounds proposing the use of novel aqueous biphasic systems (ABS) composed of quaternary ammonium compounds and different salts to the extraction of active substances from pharmaceutical wastes. The phase diagrams of ABS of six quaternary ammonium halides ([N-2,N-2,N-2,N-2]Br, [N-2,N-2,N-2,N-2]Cl, [N-3,N-3,N-3,N-3]Cl, [N-4,N-4,N-4,N-4]Br and [N-4,N-4,N-4,N-4]Cl) and three different salts (potassium citrate buffer, potassium carbonate and potassium phosphate buffer) were established at 298 (+/- 1) K. These systems allow the investigation of the influence of the ammonium structure, the salting-out agent, and the pH of the aqueous medium. They were then applied to the extraction of paracetamol that displays an extensive partition towards the ammonium-rich phase. All the studied systems, employing both the model compound and real matrix reveal a great aptitude to recover paracetamol from pharmaceutical wastes, presenting extraction efficiencies ranging from around 80% up to 100%. (c) 2013 Elsevier B.V. All rights reserved.
publisher ELSEVIER SCIENCE BV
issn 1383-5866
year published 2014
volume 122
beginning page 315
ending page 322
digital object identifier (doi) 10.1016/j.seppur.2013.11.018
web of science category Engineering, Chemical
subject category Engineering
unique article identifier WOS:000331422800041

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