Efficient Synthesis of Highly Enantioenriched Delta(1)-Pyrrolines
authors Resende, DISP; Guieu, S; Oliva, CG; Silva, AMS
nationality International
journal SYNLETT
author keywords pyrrolines; reductive cyclization; Michael addition; stereoselectivity
keywords ONE-POT SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; NITROMETHANE; PYRROLINES
abstract A general and efficient asymmetric synthesis of (1)-pyrrolines by a one-pot nitro-reduction, cyclization, and dehydration of (R,E)-1,5-diphenyl-3-(nitromethyl)-5-pent-4-en-1-ones with iron and aqueous hydrochloric acid has been developed. The (1)-pyrrolines were obtained with excellent enantioselectivities (up to 99%) and high yields (up to 83%).
publisher GEORG THIEME VERLAG KG
issn 0936-5214
year published 2015
volume 26
issue 6
beginning page 846
ending page 850
digital object identifier (doi) 10.1055/s-0034-1380144
web of science category Chemistry, Organic
subject category Chemistry
unique article identifier WOS:000351583700024
  ciceco authors
  impact metrics
journal analysis (jcr 2017):
journal impact factor 2.369
5 year journal impact factor 2.018
category normalized journal impact factor percentile 58.772
dimensions (citation analysis):
altmetrics (social interaction):



 


Apoio

1suponsers_list_ciceco.jpg