Injectability of calcium phosphate pastes: Effects of particle size and state of aggregation of beta-tricalcium phosphate powders
authors Torres, PMC; Gouveia, S; Olhero, S; Kaushal, A; Ferreira, JMF
nationality International
journal ACTA BIOMATERIALIA
author keywords Calcium phosphates; Bone cements; Injectability; Aggregation state; Particle size distribution
keywords BONE CEMENTS; LIMITED INJECTABILITY; STRENGTH IMPROVEMENT; HYPODERMIC INJECTION; IONIC MODIFICATION; CRYSTAL-STRUCTURE; APATITE CEMENT; PACKING; ADDITIVES; STRONTIUM
abstract The present study discloses a systematic study about the influence of some relevant experimental variables on injectability of calcium phosphate cements. Non-reactive and reactive pastes were prepared, based on tricalcium phosphate doped with 5 mol% (Sr-TCP) that was synthesised by co-precipitation. The varied experimental parameters included: (i) the heat treatment temperature within the range of 800-1100 degrees C; (ii) different milling extents of calcined powders; (iii) the liquid-to-powder ratio (LPR); (iv) the use of powder blends with different particle sizes (PS) and particle size distributions (PSD); (v) the partial replacement of fine powders by large spherical dense granules prepared via freeze granulation method to simulate coarse individual particles. The aim was contributing to better understanding of the effects of PS, PSD, morphology and state of aggregation of the starting powders on injectability of pastes produced thereof. Powders heat treated at 800 and 1000 degrees C with different morphologies but with similar apparent PSD curves obtained by milling/blending originated completely injectable reactive cement pastes at low LPR. This contrasted with non-reactive systems prepared thereof under the same conditions. Hypotheses were put forward to explain why the injectability results collected upon extruding non-reactive pastes cannot be directly transposed to reactive systems. The results obtained underline the interdependent roles of the different powder features and ionic strength in the liquid media on determining the flow and injectability behaviours. (C) 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
publisher ELSEVIER SCI LTD
issn 1742-7061
year published 2015
volume 21
beginning page 204
ending page 216
digital object identifier (doi) 10.1016/j.actbio.2015.04.006
web of science category Engineering, Biomedical; Materials Science, Biomaterials
subject category Engineering; Materials Science
unique article identifier WOS:000356546500018
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journal impact factor 6.383
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