Pyrazolyl Pd(II) complexes containing triphenylphosphine: Synthesis and antimycobacterial activity
authors da Silva, C; Ribeiro, LB; Furuno, CC; da Cunha, GA; de Souza, RFF; Netto, AVG; Mauro, AE; Frem, RCG; Fernandes, JA; Paz, FAA; Marino, LB; Pavan, FR; Leite, CQF
nationality International
journal POLYHEDRON
author keywords Pd(II) compounds; Triphenylphosphine; Pyrazoles; Spectroscopy; Mycobacterium tuberculosis
keywords TUBERCULOSIS PANTOTHENATE SYNTHETASE; ALAMAR BLUE ASSAY; MYCOBACTERIUM-TUBERCULOSIS; PALLADIUM(II) COMPLEXES; BIOLOGICAL EVALUATION; STRUCTURAL-CHARACTERIZATION; SUPRAMOLECULAR CHEMISTRY; N BOND; LIGANDS; INHIBITORS
abstract Complexes of the type trans-[PdCl2(HL)(PPh3)], where HL = pyrazole (1); 3,5-dimethylpyrazole (2); 4-nitropyrazole (3); 4-iodopyrazole (4) and PPh3 = triphenylphosphine, were synthesized and characterized by elemental analyses, infrared and H-1 NMR spectroscopies. Single-crystal X-ray diffraction determination on 3.0.9 CHCl3 and 4 showed that the coordination geometry around Pd(II) is nearly square-planar, with the chloro ligands in a trans configuration. In vitro antimycobacterial evaluation demonstrated that compound 4 displayed a minimum inhibitory concentration (MIC) of 7.61 +/- 2.18 mu M, being superior to the values observed for some commonly used antituberculosis drugs and other metal-based complexes. (C) 2015 Elsevier Ltd. All rights reserved.
publisher PERGAMON-ELSEVIER SCIENCE LTD
issn 0277-5387
year published 2015
volume 100
beginning page 10
ending page 16
digital object identifier (doi) 10.1016/j.poly.2015.07.009
web of science category Chemistry, Inorganic & Nuclear; Crystallography
subject category Chemistry; Crystallography
unique article identifier WOS:000365363100002
  ciceco authors
  impact metrics
journal analysis (jcr 2017):
journal impact factor 2.067
5 year journal impact factor 1.870
category normalized journal impact factor percentile 54.594
dimensions (citation analysis):
altmetrics (social interaction):



 


Apoio

1suponsers_list_ciceco.jpg