Dual functionality of phosphonic-acid-appended phthalocyanines: inhibitors of urokinase plasminogen activator and anticancer photodynamic agents
authors Venkatramaiah, N; Pereira, PMR; Paz, FAA; Ribeiro, CAF; Fernandes, R; Tome, JPC
nationality International
journal CHEMICAL COMMUNICATIONS
keywords THERAPY; CANCER; SYSTEM; PHOTOSENSITIZERS; RECEPTOR; ANALOGS
abstract Phthalocyanines (Pcs) bearing phosphonic acid groups at the periphery exhibit a potential photodynamic effect to induce photo-toxicity on human bladder cancer epithelial cells (UM-UC-3). In vitro photophysical and biological studies show high intrinsic ability to inhibit the activity of urokinase plasminogen activator (uPA) and matrix metalloproteinase-9 (MMP-9).
publisher ROYAL SOC CHEMISTRY
issn 1359-7345
year published 2015
volume 51
issue 85
beginning page 15550
ending page 15553
digital object identifier (doi) 10.1039/c5cc06561e
web of science category Chemistry, Multidisciplinary
subject category Chemistry
unique article identifier WOS:000363167900017
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  impact metrics
journal analysis (jcr 2017):
journal impact factor 6.290
5 year journal impact factor 6.064
category normalized journal impact factor percentile 83.918
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