Studies on polymorph conversion in a new cyclodextrin inclusion compound
authors Fernandes, JA; Ramos, AI; Ribeiro-Claro, P; Paz, FAA; Braga, SS
nationality International
journal CRYSTENGCOMM
keywords N-OXIDE DERIVATIVES; METAL-ORGANIC FRAMEWORKS; C-13 CHEMICAL-SHIFTS; BETA-CYCLODEXTRIN; SOLID-STATE; AQUEOUS-SOLUTION; ANTIMICROBIAL ACTIVITY; ALLIUM-STIPITATUM; SOLUTION NMR; COMPLEX
abstract A novel beta-cyclodextrin (beta CD) inclusion compound was prepared using 4-phenylpyridine-N-oxide (PPNO) as the organic guest. The inclusion compound, beta CD.PPNO, was characterised both in solution and in the solid state using numerous techniques. H-1 NMR in aqueous solution allowed the determination of a 1 : 1 stoichiometry and an association constant of 164 +/- 21 M-1. Powder and single-crystal X-ray diffraction studies showed the formation of two distinct crystal phases, appearing at different timings. Over time, one of the crystal phases converts spontaneously into the other. This work is the first to monitor the conversion of different polymorphs of cyclodextrin inclusion compounds in real time.
publisher ROYAL SOC CHEMISTRY
issn 1466-8033
year published 2015
volume 17
issue 4
beginning page 937
ending page 946
digital object identifier (doi) 10.1039/c4ce02041c
web of science category Chemistry, Multidisciplinary; Crystallography
subject category Chemistry; Crystallography
unique article identifier WOS:000346897500028
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journal analysis (jcr 2017):
journal impact factor 3.304
5 year journal impact factor 3.222
category normalized journal impact factor percentile 67.594
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