Coating Strategies Using Layer-by-layer Deposition for Cell Encapsulation
authors Oliveira, MB; Hatami, J; Mano, JF
nationality International
journal CHEMISTRY-AN ASIAN JOURNAL
author keywords cell encapsulation; cell nanomodification; hollow capsules; layer-by-layer; nanocoatings
keywords POLYELECTROLYTE MULTILAYER FILMS; EXTRACELLULAR-MATRIX FILMS; ISLET TRANSPLANTATION; PANCREATIC-ISLETS; LIVING CELLS; STEM-CELLS; BIOMEDICAL APPLICATIONS; ENDOTHELIAL-CELLS; COMPLEX MEMBRANE; THIN-FILMS
abstract The layer-by-layer (LbL) deposition technique is widely used to develop multilayered films based on the directed assembly of complementary materials. In the last decade, thin multilayers prepared by LbL deposition have been applied in biological fields, namely, for cellular encapsulation, due to their versatile processing and tunable properties. Their use was suggested as an alternative approach to overcome the drawbacks of bulk hydrogels, for endocrine cells transplantation or tissue engineering approaches, as effective cytoprotective agents, or as a way to control cell division. Nanostructured multilayered materials are currently used in the nanomodification of the surfaces of single cells and cell aggregates, and are also suitable as coatings for cell-laden hydrogels or other biomaterials, which may later be transformed to highly permeable hollow capsules. In this Focus Review, we discuss the applications of LbL cell encapsulation in distinct fields, including cell therapy, regenerative medicine, and biotechnological applications. Insights regarding practical aspects required to employ LbL for cell encapsulation are also provided.
publisher WILEY-V C H VERLAG GMBH
issn 1861-4728
year published 2016
volume 11
issue 12
beginning page 1753
ending page 1764
digital object identifier (doi) 10.1002/asia.201600145
web of science category Chemistry, Multidisciplinary
subject category Chemistry
unique article identifier WOS:000379519400001
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journal analysis (jcr 2019):
journal impact factor 4.056
5 year journal impact factor 3.628
category normalized journal impact factor percentile 69.774
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