General optimization strategy of simulated moving bed units through design of experiments and response surface methodologies
authors Aniceto, JPS; Cardoso, SP; Silva, CM
nationality International
journal COMPUTERS & CHEMICAL ENGINEERING
author keywords Chromatography; Design of experiments; Enantiomers; Simulated moving bed; Trans-stilbene oxide
keywords TROGERS BASE ENANTIOMERS; SMB CHROMATOGRAPHY; CHIRAL SEPARATION; STATIONARY-PHASE; SYSTEMS; OPERATION; OD
abstract The optimization of simulated moving bed (SMB) units is often performed through detailed phenomenological models and require extensive computation time. Hence several optimization methods like the Triangle Theory, and the concept of separation volume have been proposed. However, they do not provide accurate results, when mass transfer limitations are significant, or require a large number of simulations. In this work, a combined Design of Experiments and Response Surface Methodology (DoE-RSM) approach is proposed for SMB optimization, aimed at providing good results with simplicity and reduced number of simulations. The separation of trans-stilbene oxide enantiomers is selected as case study in order to compare DoE-RSM with previous approaches. In the whole, accurate results are obtained with a few number of simulations, allowing for purities above 99.60% for both enantiomers, and productivity of 65.41 kg/(m(adsorbent)(3) day). The versatility of DoE-RSM tool is also discussed, emphasising their advantages and general applicability. (C) 2016 Elsevier Ltd. All rights reserved.
publisher PERGAMON-ELSEVIER SCIENCE LTD
issn 0098-1354
year published 2016
volume 90
beginning page 161
ending page 170
web of science category Computer Science, Interdisciplinary Applications; Engineering, Chemical
subject category Computer Science; Engineering
unique article identifier WOS:000376406100012
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journal analysis (jcr 2017):
journal impact factor 3.113
5 year journal impact factor 3.206
category normalized journal impact factor percentile 76.218
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