Improved extraction of fluoroquinolones with recyclable ionic-liquid-based aqueous biphasic systems
authors Almeida, HFD; Freire, MG; Marrucho, IM
nationality International
journal GREEN CHEMISTRY
keywords WASTE-WATER TREATMENT; PERSONAL CARE PRODUCTS; TREATMENT PLANTS; 2-PHASE SYSTEMS; PHARMACEUTICAL RESIDUES; AQUATIC ENVIRONMENT; ALUMINUM PHOSPHATE; RISK-ASSESSMENT; CONTAMINANTS; REMOVAL
abstract In the past few years, the improvement of advanced analytical tools allowed to confirm the presence of trace amounts of metabolized and unchanged active pharmaceutical ingredients (APIs) in wastewater treatment plants (WWTPs) as well as in freshwater surfaces. It is known that the continuous contact with APIs, even at very low concentrations (ng L-1-mu gL(-1)), leads to serious human health problems. In this context, this work shows the feasibility of using ionic-liquid-based aqueous biphasic systems (IL-based ABS) in the extraction of quinolones present in aqueous media. In particular, ABS composed of imidazolium- and phosphonium-based ILs and aluminium-based salts (already used in water treatment plants) were evaluated in one-step extractions of six fluoroquinolones (FQs), namely ciprofloxacin, enrofloxacin, moxifloxacin, norfloxacin, ofloxacin and sarafloxacin, and extraction efficiencies up to 98% were obtained. Despite the large interest devoted to IL-based ABS as extractive systems of outstanding performance, their recyclability/reusability has seldomly been studied. An efficient extraction/cleaning process of the IL-rich phase is here proposed by FQs induced precipitation. The recycling of the IL and its further reuse without losses in the ABS extractive performance for FQs were established, as confirmed by the four consecutive removal/extraction cycles evaluated. This novel recycling strategy supports IL-based ABS as sustainable and cost-efficient extraction platforms.
publisher ROYAL SOC CHEMISTRY
issn 1463-9262
year published 2016
volume 18
issue 9
beginning page 2717
ending page 2725
digital object identifier (doi) 10.1039/c5gc02464a
web of science category Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY
subject category Chemistry; Science & Technology - Other Topics
unique article identifier WOS:000375291100020
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journal analysis (jcr 2017):
journal impact factor 8.586
5 year journal impact factor 8.717
category normalized journal impact factor percentile 91.733
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