Role of Isoprenoid Compounds on Angiogenic Regulation: Opportunities and Challenges
authors Guerra, AR; Duarte, IF; Duarte, MF
nationality International
journal CURRENT MEDICINAL CHEMISTRY
author keywords Angiogenesis; Natural products; Monoterpenoids; Sesquiterpenoids; Diterpenoids; Triterpenoids; Tetraterpenoids
keywords ENDOTHELIAL-GROWTH-FACTOR; NF-KAPPA-B; INHIBITS TUMOR ANGIOGENESIS; CELLS IN-VITRO; BREAST-CANCER CELLS; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; MULTIPLE-MYELOMA CELLS; SMOOTH-MUSCLE-CELLS; URSOLIC ACID; BETA-CAROTENE
abstract Isoprenoids represent one of the largest classes of phytochemicals. The structural diversity of these compounds, as well as their remarkable biological activities, makes them suitable candidates for the development of novel therapeutic agents. Several isoprenoids have demonstrated promising potential in the modulation of angiogenesis processes, and therefore provide an appealing alternative and/or addition to the available pharmacotherapies. These compounds could be used per se or combined with standard therapies, which can potentially reduce the undesired secondary effects. Compounds like the sesquiterpenoid artemisinin, and its derivatives, or the diterpenoid triptolide have been successfully tested in a broad range of models (in vitro and in vivo). Moreover, sesquiterpenoids seem to be a promising resource of natural angiogenic modulators, as it can be attested by the significant number of recent publications in this subject. On the other hand, other isoprenoids, such as the triterpenoid ursolic acid, are still under-explored and further studies are needed to understand their role within angiogenic process. Further insights into isoprenoids mode of action in angiogenesis will hopefully pave the way towards their successful clinical use.
publisher BENTHAM SCIENCE PUBL LTD
issn 0929-8673
year published 2016
volume 23
issue 9
beginning page 911
ending page 928
digital object identifier (doi) 10.2174/0929867323666160217123822
web of science category Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology & Pharmacy
subject category Biochemistry & Molecular Biology; Pharmacology & Pharmacy
unique article identifier WOS:000372850600006
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journal analysis (jcr 2017):
journal impact factor 3.469
5 year journal impact factor 3.519
category normalized journal impact factor percentile 71.089
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