Permeation of skin with (C-60) fullerene dispersions
authors Martins, M; Azoia, NG; Melle-Franco, M; Ribeiro, A; Cavaco-Paulo, A
nationality International
journal ENGINEERING IN LIFE SCIENCES
author keywords Cosmetics; Delivery; Dispersion; Fullerene C-60; Transdermal
keywords IN-VITRO; PERCUTANEOUS-ABSORPTION; TRANSDERMAL PERMEATION; LIPID-PEROXIDATION; MOLECULAR-DYNAMICS; STRATUM-CORNEUM; SOLUBILITY; MODEL; PIG; NANOMATERIALS
abstract Dispersions in transcutol/isopropylmyristate make C-60 fullerenemolecules suitable for transdermal delivery. We found that C-60 can successfully permeate the skin using pig skin in Franz diffusion cells. Molecular dynamics simulations and transmission electron microscopy confirmed these observations. Basic cosmetic formulations with transcutol/isopropylmyristate without harsh organic solvents show a high potential for delivery of C-60 for biopharmaceutical and cosmetics applications.
publisher WILEY
issn 1618-0240
isbn 1618-2863
year published 2017
volume 17
issue 7
beginning page 732
ending page 738
digital object identifier (doi) 10.1002/elsc.201600244
web of science category Biotechnology & Applied Microbiology
subject category Biotechnology & Applied Microbiology
unique article identifier WOS:000412288400003
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journal analysis (jcr 2017):
journal impact factor 2.385
5 year journal impact factor 2.578
category normalized journal impact factor percentile 54.969
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