|
authors |
Braga, SS; Marques, J; Fernandes, JA; Paz, FAA; Marques, MPM; Santos, TM; Silva, AMS |
|
nationality |
International |
|
journal |
CHEMICAL PAPERS |
|
author keywords |
Cyclodextrin inclusion; Host-guest chemistry; Ru(II)-dipyridylamine complex; Solid-state; Osteosarcoma chemotherapy |
|
keywords |
MOLYBDENOCENE DICHLORIDE CP2MOCL2; X-RAY-DIFFRACTION; COMPLEX NAMI-A; RUTHENIUM COMPLEX; INCLUSION COMPOUND; STRUCTURAL-CHARACTERIZATION; ANTICANCER ACTIVITY; OSTEOSARCOMA CELLS; ARENE COMPLEXES; INHIBITION |
|
abstract |
The complex [([9]aneS(3))Ru-II(dipa)Cl]Cl (1, where dipa = 2,2'-dipyridylamine) was included into native beta-cyclodextrin (beta-CD) and permethylated beta-CD (TRIMEB) by co-dissolution followed by solvent removal. Two adducts were obtained with a 1:1 host:guest stoichiometry. Solid-state studies of the guest comprised collecting the single-crystal structure of its 3.5 hydrate form and also powder diffraction on the remaining bulk material, showing it is isotypical with the harvested crystal for X-ray analysis. Solid-state studies of the cyclodextrin adducts were carried out by powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA), C-13{H-1} CP/MAS NMR and FTIR spectroscopies. Biological studies on 1 and its adducts comprised the evaluation of the shift caused by 1 on the melting temperature of DNA (Delta T (m)), as well as the evaluation of cytotoxicity by the MTT assay on the osteosarcoma MG-63 cell line. |
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publisher |
SPRINGER INTERNATIONAL PUBLISHING AG |
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issn |
0366-6352 |
|
isbn |
1336-9075 |
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year published |
2017 |
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volume |
71 |
|
issue |
7 |
|
beginning page |
1235 |
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ending page |
1248 |
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digital object identifier (doi) |
10.1007/s11696-016-0117-0 |
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web of science category |
Chemistry, Multidisciplinary |
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subject category |
Chemistry |
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unique article identifier |
WOS:000403321900006
|
