Supramolecular adducts of native and permethylated beta-cyclodextrins with (2,2'-dipyridylamine)chlorido(1,4,7-trithiacyclononane)ruthenium(II) chloride: solid-state and biological activity studies
authors Braga, SS; Marques, J; Fernandes, JA; Paz, FAA; Marques, MPM; Santos, TM; Silva, AMS
nationality International
journal CHEMICAL PAPERS
author keywords Cyclodextrin inclusion; Host-guest chemistry; Ru(II)-dipyridylamine complex; Solid-state; Osteosarcoma chemotherapy
keywords MOLYBDENOCENE DICHLORIDE CP2MOCL2; X-RAY-DIFFRACTION; COMPLEX NAMI-A; RUTHENIUM COMPLEX; INCLUSION COMPOUND; STRUCTURAL-CHARACTERIZATION; ANTICANCER ACTIVITY; OSTEOSARCOMA CELLS; ARENE COMPLEXES; INHIBITION
abstract The complex [([9]aneS(3))Ru-II(dipa)Cl]Cl (1, where dipa = 2,2'-dipyridylamine) was included into native beta-cyclodextrin (beta-CD) and permethylated beta-CD (TRIMEB) by co-dissolution followed by solvent removal. Two adducts were obtained with a 1:1 host:guest stoichiometry. Solid-state studies of the guest comprised collecting the single-crystal structure of its 3.5 hydrate form and also powder diffraction on the remaining bulk material, showing it is isotypical with the harvested crystal for X-ray analysis. Solid-state studies of the cyclodextrin adducts were carried out by powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA), C-13{H-1} CP/MAS NMR and FTIR spectroscopies. Biological studies on 1 and its adducts comprised the evaluation of the shift caused by 1 on the melting temperature of DNA (Delta T (m)), as well as the evaluation of cytotoxicity by the MTT assay on the osteosarcoma MG-63 cell line.
publisher SPRINGER INTERNATIONAL PUBLISHING AG
issn 0366-6352
isbn 1336-9075
year published 2017
volume 71
issue 7
beginning page 1235
ending page 1248
digital object identifier (doi) 10.1007/s11696-016-0117-0
web of science category Chemistry, Multidisciplinary
subject category Chemistry
unique article identifier WOS:000403321900006
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journal impact factor 0.963
5 year journal impact factor 1.198
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